Investigating on pathophysiology of Irritable Bowel Syndrome (IBS) and its associating genetic derangements: A review study

Introduction: Irritable Bowel Syndrome (IBS) is known as a prevalent, long-term condition of the digestive system, which affect a significant proportion of societies.Methods: In the current study, we have reviewed and investigated on the conducted researches covering IBS pathophysiology and the genes associated  with the manifestation of the syndrome.Findings: Throughout the published literature about IBS, various environmental factors as well as the influence of particular genes have been introduced as the underlying causes of raising IBS. This study is an effort to review, assess and collect data on multiple causes which leads to IBS manifestation.Conclusion: Although no certain and definite cause of IBS was found throughout searched and reviewed articles, factors such as stresses, childhood events, previous bowel infection, neurotransmitter changes in brain and genetic alterations have been described and explained through articles. Diagnosing IBS should be done precautiously and primary examinations on inspecting organic diseases in the digestive system should take place prior to diagnosis of the syndrome